Systematic comparison of gliflozins identifies a selective anti-calcifying effect of canagliflozin beyond canonical SGLT2 inhibition
Lucie Fernandez, Manon Brunet, Emma Ballongue, Victor Ducos, Marie Buleon, Guylene Feuillet, Eduardo Galaricha, Aline Mairal, Arnaud Del Bello, Nathalie Auge, Nathalie Gayrard, Jonas Laguet, Fabrice Raynaud, Juan Miguel Diaz-Tocados, Arthur Thomas, , Julie Klein
This study compares gliflozins and finds canagliflozin uniquely reduces vascular calcification through mechanisms beyond SGLT2 inhibition, affecting VSMC metabolism and calcification.
bioRxiv · Nov 6, 2026 · PreprintPathology