Early sex-specific organ transcriptional divergence without physiological differences in a murine model of fecal-induced peritonitis
Alexandra Troitskaya, Aminmohamed Manji, Onon Batnyam, Eric K. Patterson, Forough Jahandideh, Dhruva J. Dwivedi, Manoj Mathew Lalu, Asher A. Mendelson, Braedon McDonald, Stephane L. Bourque, Kimberly F. Macala, Alison Fox‐Robichaud, Patricia C. Liaw, Gediminas Cepinskas, Ruud A. W. Veldhuizen, Sean E. Gill
This study examines early septic responses in male and female mice, finding sex-specific transcriptional differences in organs without physiological differences.
bioRxiv · Feb 19, 2026 · PreprintPathology