Standard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition
Romain Guiho, Hiba Hamdi, Grace Cooksley, Timoty H. Chang, Le Cao, Romain Sigaud, Sophie Bliss, Ashley Vardon, Scott Haston, Florian Selt, Akang Leonard Bassey, Daniela Kocher, Ria Kedia, Daniel Gharai, Jesús Gil, , Juan Pedro Martinez Barbera
This study shows that standard therapies for paediatric BRAF-V600E glioma induce senescence, which can be targeted by BCL-xL inhibitors to prevent tumour regrowth.
Neuro-Oncology · Oct 28, 2026Peer-reviewedCancer Biology