Pulmonary Hypertension Promotes Neuroinflammation and Neurodegeneration
P. De La Cruz, Angelia D. Lockett, Marta Teixeira Gomes, Somanshu Banerjee, Asif Razee, Amanda Jo Fisher, Todd G. Cook, Christopher D Lloyd, Shino Magaki, Soban Umar, Adrian L. Oblak, Roberto F. Machado
This study shows that pulmonary hypertension increases microglia and astrocyte density, reduces neuronal density, and causes TDP-43 mislocalization in both rat and human brain tissue.
bioRxiv · Sep 2, 2025 · PreprintPhysiology