Triple-Negative Breast Cancer Cells Activate Sensory Neurons via TRPV1 to Drive Nerve Outgrowth and Tumor Progression
Hanan Bloomer, Savannah R. Parker, Audrey L. Pierce, Wesley P. Clawson, Mallory M. Caron, Thomas J. Gerton, Ankit Pandey, Thanh Thien Le, Tolulope Adewumi, Charlotte Kuperwasser, Michael G. Levin, Madeleine Julie Oudin
This study shows TNBC cells activate sensory neurons via TRPV1, driving nerve outgrowth and tumor progression, with TRPV1 knockout reducing tumor growth and metastasis.
bioRxiv · Jul 22, 2025 · PreprintCancer Biology