Epigenetic reprogramming of autophagy leads to uncovering a novel therapeutic target for mutant IDH1 astrocytomas
Felipe Javier Núñez, Kaushik Banerjee, Anzar A. Mujeeb, Ava Mauser, Claire E. Tronrud, Ziwen Zhu, Sadhakshi Raghuram, Maya R. Sheth, Jorge Armando Pena Agudelo, Julio Zelaya, Ayman W. Taher, Padma Kadiyala, Stephen V. Carney, María Belén Garcia-Fabiani, Andrea Comba, , Maria Graciela Castro
This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.
bioRxiv · Mar 8, 2024 · PreprintCancer Biology