Andrea Comba

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

This paper models glioma oncostreams in vitro, showing their formation, stability, and response to pharmacological agents, with insights into potential anti-invasion targets.

The paper uses an agent-based model to show that glioma cell morphology and density influence self-organization patterns like flocks and streams, with higher density reducing flocks and increasing streams, linking these patterns to tumor malignancy.