Author

B. Balcomb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:virus· 1

Frequent Co-Authors

A. Schutzer de Godoy· 2 shared A. V. Chandran· 2 shared C. Giroud· 2 shared C. W. E. Tomlinson· 2 shared C. Wild· 2 shared D. FearoniD· 2 shared E. M. MacLean· 2 shared E. P. Williams· 2 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. Schutzer de Godoy

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2 papers

Recent·Most cited

Crystallographic fragment screen of Enterovirus D68 3C protease and iterative design of lead-like compounds using structure-guided expansions

R. M. Lithgo, C. W. E. Tomlinson, M. Fairhead, M. Winokan, W. Thompson, C. Wild, J. Aschenbrenner, B. Balcomb, P. G. Marples, A. V. Chandran, M. N. Golding, L. Koekemoer, E. P. Williams, S. Wang, X. Ni, , F. von Delft

This study identifies fragments binding to EV-D68 3C protease through crystallography and expands them into lead-like compounds, revealing novel binding modes and structural insights for drug design.

bioRxiv · Apr 29, 2024 · PreprintBiochemistry

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals

The paper identifies 75 fragments that bind to Coxsackievirus A16 2A protease, including 38 unique compounds in the active site, offering a path for broad-spectrum anti-enteroviral inhibitors.

bioRxiv · Apr 29, 2024 · PreprintBiochemistry