C. Wild

Crystallographic fragment screen of Enterovirus D68 3C protease and iterative design of lead-like compounds using structure-guided expansions

This study identifies fragments binding to EV-D68 3C protease through crystallography and expands them into lead-like compounds, revealing novel binding modes and structural insights for drug design.

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals

The paper identifies 75 fragments that bind to Coxsackievirus A16 2A protease, including 38 unique compounds in the active site, offering a path for broad-spectrum anti-enteroviral inhibitors.

Short periods of decreased water flow may modulate long-term ocean acidification in reef-building corals

This study investigates how short periods of decreased water flow affect coral physiology under ocean acidification, finding species-specific responses and potential mitigation of OA effects.

Accelerated Nitrogen Cycling on Seagrass Leaves in a High-CO2 World

The paper shows that ocean acidification increases nitrogen gain and N2 fixation in seagrass leaves, with microbial communities playing a key role in nitrogen cycling.

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

The paper identifies fragment hits against SARS-CoV-2 main protease using crystallography and mass spectrometry, revealing structural insights for drug design.