S. Wang

Microfluidic Tissue Array Platform for Personalized Drug Screening Using Tumor Explants or Biopsies

This paper develops a microfluidic tissue array platform for personalized drug screening using tumor explants or biopsies, showing reduced tumor cell viability and proliferative cell retention after treatment.

CsFDL1-CsFTL3 complex represses CsFTL3 via negative feedback to fine-tune flowering in Chrysanthemum seticuspe

This study identifies a negative feedback loop where CsFDL1 represses CsFTL3 to regulate flowering timing in Chrysanthemum seticuspe under short-day conditions.

Structural and dynamic studies uncover a distinct allosteric modulatory site at the mu-opioid receptor

This study identifies a novel allosteric site on the mu-opioid receptor using cryo-EM and MD simulations, revealing a lipid-sensitive mechanism for positive allosteric modulation.

Genetically Engineered Cell Membrane-Coated Nanodrug for Targeted Treatment of Thyroid Cancer

This study develops a nanodrug, mPDS@CAR-M, for targeted treatment of RAIR-DTC by combining chemotherapy, photothermal therapy, and tumor cell membrane coating to enhance tumor targeting and therapeutic efficacy.

Artificial light at night alters morphology, phenology, and reproductive capacity in an annual herb

This study shows that artificial light at night changes plant morphology, reproductive timing, and capacity in Elsholtzia densa, with mixed effects on fitness.

An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries

This study uses live-cell single-molecule tracking in yeast to analyze the dynamics of RNA polymerase machineries, revealing new insights into transcriptional processes and the role of the CTD in splicing.

Polycystin-1 loss of function increases susceptibility to atrial fibrillation through impaired DNA damage response

NSP4 mutation T492I drives rapid evolution of SARS-CoV-2 toward Omicron

This study shows that the NSP4 T492I mutation increases SARS-CoV-2 mutation rates and accelerates the emergence of Omicron-like mutations.

A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome

The paper identifies a Pseudomonas aeruginosa VgrG2b fragment cleaved by caspase-11 that inhibits NLRP3 inflammasome activation, promoting infection and improving survival with a specific peptide inhibitor.

Discovery of a Heparan Sulfate Binding Domain in Monkeypox Virus H3 as an Anti-poxviral Drug Target Combining AI and MD Simulations

The paper identifies a conserved heparan sulfate binding domain in MPXV H3 using AI and MD simulations, validates its role in viral adhesion, and demonstrates a protein inhibitor that disrupts this interaction, inhibiting infection in vitro and in vivo.

Notch Signaling in regulating Bone-derived Nanoparticles (BNPs) enhanced Osteogenic Differentiation

This study investigates how bone-derived nanoparticles (BNPs) enhance osteogenic differentiation of mesenchymal stem cells (MSCs) through Notch signaling, specifically by increasing Dll4 expression.

Os-circANK negatively regulates resistance to bacterial blight in rice via Osa-miR398b/OsCSD1/OsCSD2 pathways

The paper identifies Os-circANK as a circRNA that suppresses rice resistance to bacterial blight by sponging Osa-miR398b and modulating OsCSD1/OsCSD2 expression.

Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide

This study compares vaccine-elicited and naturally elicited antibodies' recognition of HIV-1 fusion peptide sequences, finding that naturally elicited antibodies show greater tolerance to sequence variation.

NF-kappaB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency

This study shows that ESCRT-I deficiency leads to metabolic reprogramming via NF-kappaB and JNK pathways, causing increased glycolysis and lipid accumulation.

M2e-Derived Peptidyl and Peptide Amphiphile Micelles as Novel Influenza Vaccines

This study develops M22-16 peptide-based micelles as a universal influenza vaccine, showing they induce strong immunological responses with a prime-booster regimen.

Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

This study shows that zebrafish gut microbiome influences protein absorption by altering lysosome-rich enterocytes' expression of digestion machinery and microbial interactions.

A Near Infrared Fluorescent Nanosensor for Spatial and Dynamic Measurements of Auxin, Indole-3-Acetic Acid, in Planta

This paper introduces a near infrared fluorescent nanosensor for spatial and dynamic measurement of IAA in planta, showing species independence and functionality in plant cells.

The maternal vGluT2 and embryonic mGluR3 signaling relay system controls offspring wing dimorphism in pea aphid

This study identifies a signaling relay system involving maternal vGluT2 and embryonic mGluR3 that controls offspring wing dimorphism in pea aphids through transgenerational phenotypic plasticity.

Phenotypic variability between closely related Trichodesmium strains as a means to making the most out of heterogeneous microenvironments

The paper investigates phenotypic variability among Trichodesmium strains in heterogeneous microenvironments using metagenomics and metatranscriptomics.

The dynamic climate adaptation of indicator warbler species complex in the Pacific Rainforest

This study analyzes climate adaptation in hybridizing warbler species using citizen science and climate data, finding differential responses and recovery patterns.

Imaging the extracellular matrix in live tissues and organisms with a glycan-binding fluorophore

This paper introduces a fluorophore for imaging extracellular matrix in live tissues and organisms by binding to glycans, enabling nonperturbative and wash-free visualization.

A New Species of Pachytriton from Anhui, China (Amphibia: Caudata: Salamandridae)

The paper describes a new salamander species, Pachytriton, from Anhui, China, based on morphological and molecular analyses.

FKBP11 targeted plasma cells promote abdominal aortic aneurysm progression through an m6A-dependent mechanism

This study identifies FKBP11's role in AAA progression via m6A-dependent mechanisms using multi-omics and machine learning.

Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation

This paper identifies GBP5 as an ISG that inhibits viral replication by blocking N-glycosylation of viral proteins, including SARS-CoV-2 spike, through interaction with the OST complex.

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors

The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.

Crystallographic fragment screen of Enterovirus D68 3C protease and iterative design of lead-like compounds using structure-guided expansions

This study identifies fragments binding to EV-D68 3C protease through crystallography and expands them into lead-like compounds, revealing novel binding modes and structural insights for drug design.

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals

The paper identifies 75 fragments that bind to Coxsackievirus A16 2A protease, including 38 unique compounds in the active site, offering a path for broad-spectrum anti-enteroviral inhibitors.

An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut

This paper develops an ingestible, battery-free robotic interface for chronic gut electrostimulation, showing it can modulate ghrelin levels and has potential for treating gastrointestinal conditions.