Dynamics of the cell-free DNA methylome of metastatic prostate cancer during androgen-targeting treatment
M. R. Peter, M. Bilenky, R. Isserlin, G. D. Bader, S. Y. Shen, D. D. De Carvalho, A. R. Hansen, P. Hu, N. E. Fleshner, A. M. Joshua, M. Hirst, B. Bapat
This study examines methylation changes in cell-free DNA of mCRPC patients during androgen-targeting therapy, finding that persistent methylation changes correlate with longer time to clinical progression.
bioRxiv · Apr 8, 2020Cancer Biology