Author

D. D. De Carvalho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1

Frequent Co-Authors

G. D. Bader· 2 shared S. A. Marhon· 2 shared A. A. Shishkin· 1 shared A. G. Trotman-Grant· 1 shared A. G. Zeng· 1 shared A. Hosseini· 1 shared A. J. Murison· 1 shared A. M. Joshua· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

G. D. Bader

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Author profile →

4 papers

Recent·Most cited

Cell BiologybioRxivMar 30, 2023

Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer

A. Hosseini, H. T. Lindholm, R. Chen…·D. D. De Carvalho

The paper identifies XRN1 as a dependency in cancer cells that control dsRNA stress through viral mimicry, revealing therapeutic opportunities.

DOI 10.1016/j.celrep.2024.113684

humanbulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivJul 30, 2021

Identification of the Global miR-130a Targetome Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML

G. Krivdova, V. Voisin, E. M. Schoof…·E. R. Lechman

This study identifies miR-130a as a regulator of HSC self-renewal and differentiation, with TBL1XR1 as a key target, and shows its role in maintaining the oncogenic program in t(8;21) AML.

DOI 10.1016/j.celrep.2022.110481

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 23, 2020

Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit

J. Salmon, I. Todorovski, S. J. Vervoort…·R. W. Johnstone

The paper shows that inhibiting HDACs in AML promotes type I IFN production by pDCs, enhancing anti-tumor immunity and therapeutic benefit.

DOI 10.1101/2020.08.23.235499

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivApr 8, 2020

Dynamics of the cell-free DNA methylome of metastatic prostate cancer during androgen-targeting treatment

M. R. Peter, M. Bilenky, R. Isserlin…·B. Bapat

This study examines methylation changes in cell-free DNA of mCRPC patients during androgen-targeting therapy, finding that persistent methylation changes correlate with longer time to clinical progression.

DOI 10.2217/epi-2020-0173

humanDNA methylation

𝕏 PostBluesky