P. Hu

Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

This study identifies human CD29+/CD56+ myogenic progenitors with tendon differentiation potential that improve tendon repair when transplanted.

Role of socioeconomic factors and interkingdom crosstalk in the dental plaque microbiome in early childhood caries

This study examines the dental plaque microbiome in early childhood caries, finding associations between specific microbes, socioeconomic factors, and host variables.

Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity

This study uses proteomic profiling to reveal lysosomal heterogeneity and its role in longevity by identifying protein dynamics and interactions in lysosomes.

Data-driven system matrix manipulation enabling fast functional imaging and intra-image nonrigid motion correction in tomography

This paper introduces methods to improve tomographic imaging by compressing system matrices and correcting motion artifacts, demonstrating improvements in 3D photoacoustic computed tomography.

Manipulation of Bacterial ROS Production Leads to Self-escalating DNA Damage and Resistance-resistant Lethality for Intracellular Mycobacteria

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics

This paper introduces a single-shot 3D photoacoustic tomography method using a single-element detector to enable ultrafast hemodynamics imaging in humans and small animals.

USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC

This study shows USP39 promotes liver cancer by regulating alternative splicing through interaction with SRSF6/HNRNPC, identifying it as a potential therapeutic target.

Structure of the ISW1a complex bound to the dinucleosome

The paper reports the cryoEM structure of the ISW1a complex bound to the dinucleosome, revealing its mechanism of nucleosome spacing and organization.

Highly synchronized cortical circuit dynamics mediate spontaneous pain

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

This study generates functional posterior spinal motor neurons from hPSCs-derived neural progenitor cells, demonstrating efficient differentiation and functional maturity.

Ameliorating Emotional Attention through Modulation of Neural Oscillations with Transcranial Alternating Current Stimulation

This study tests the effect of transcranial alternating current stimulation (tACS) on emotional attention, finding increased alpha power and improved ERP responses in the active group.

De novo germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice

This study identifies a de novo germline mutation in Dusp10 that accelerates autoimmune diabetes in NOD mice by increasing susceptibility through CRISPR validation and PD-L1 expression analysis.

Loss of FSTL1-expressing adipocyte progenitors drives the age-related involution of brown adipose tissue

This study identifies FSTL1-expressing adipocyte progenitors as drivers of age-related brown adipose tissue involution in rabbits and humans, with loss of FSTL1 causing iBAT atrophy in mice.

Dynamics of the cell-free DNA methylome of metastatic prostate cancer during androgen-targeting treatment

This study examines methylation changes in cell-free DNA of mCRPC patients during androgen-targeting therapy, finding that persistent methylation changes correlate with longer time to clinical progression.

Elucidation of the determinant for orchestration of solo unisexual cycle in an important human fungal pathogen

This study identifies Cqs2 as the critical determinant for orchestrating the unisexual cycle in Cryptococcus neoformans without requiring the sex-determination program.

Unusual metabolism and hypervariation in the genome of a Gracilibacteria (BD1-5) from an oil degrading community

The paper reports the first closed genome of a Gracilibacteria from an oil-degrading community, revealing unusual metabolism and a hypervariable repeat region with potential functional significance.

Analysis of small RNA silencing in Zymoseptoria tritici - wheat interactions

This study investigates RNAi pathways in Zymoseptoria tritici and their role in pathogenesis, finding that RNAi components are dispensable for infection and that sRNA biogenesis may involve non-canonical pathways.

Acute and chronic toxicity assessment of benzylpenicillin G residues in heat-treated animal food products

This study assesses the acute and chronic toxicity of benzylpenicillin G residues in heat-treated animal food products using a mouse model, finding reduced LD50 and organ damage at high exposure levels.

Metabolic and spatio-taxonomic response of uncultivated seafloor bacteria following the Deepwater Horizon oil spill

The paper examines the metabolic and taxonomic responses of uncultivated seafloor bacteria after the Deepwater Horizon oil spill, identifying genes and expression patterns related to hydrocarbon degradation.