High levels of frataxin overexpression leads to mitochondrial and cardiac toxicity in mouse models
B. Belbellaa, L. Reutenauer, N. Messaddeq, L. Monassier, H. Puccio
This study shows that high frataxin overexpression in mouse models causes mitochondrial and cardiac toxicity, with toxicity emerging above 20-fold normal levels.
bioRxiv · Mar 31, 2020Bioengineering