Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain
V. Dubey, B. Bozorg, D. Wuestner, H. Khandelia
This study shows that cholesterol binding to the SSD of NPC1 restricts NTD dynamics, suggesting an allosteric feedback mechanism regulating lysosomal cholesterol levels.
bioRxiv · Nov 25, 2019Biophysics