Efficient formation and maintenance of humoral and CD4 T cell immunity targeting the viral capsid in acute-resolving hepatitis E infection
B. Csernalabics, M. S. Marinescu, L. Maurer, L. Kelsch, J. Werner, K. Baumann, K. Zoldan, M. Panning, P. Reuken, T. Bruns, B. Bengsch, C. Neumann-Haefelin, M. Hofmann, R. Thimme, V. L. Dao Thi, T. Boettler
The paper longitudinally characterizes HEV-specific CD4 T cells and neutralizing antibodies targeting nHEV and eHEV in acute and resolved HEV infection, finding capsid-specific immunity dominates and correlates with nAb responses.
bioRxiv · Oct 19, 2023Immunology