B. Bengsch

Efficient formation and maintenance of humoral and CD4 T cell immunity targeting the viral capsid in acute-resolving hepatitis E infection

The paper longitudinally characterizes HEV-specific CD4 T cells and neutralizing antibodies targeting nHEV and eHEV in acute and resolved HEV infection, finding capsid-specific immunity dominates and correlates with nAb responses.

Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment

This study identifies a PGE2-autophagy-glutathione axis that enables CD8+ T cells to adapt metabolically to the intestinal microenvironment.

Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues

This study uses capillary electrophoresis mass spectrometry to identify new isomers of inositol pyrophosphates in mammalian tissues and patient samples.

Adaptive subsets limit the anti-tumoral NK-cell activity in Hepatocellular Carcinoma

This study shows that adaptive NK cells have reduced anti-tumoral activity in HCC patients, particularly in those with HBV infection, and are expanded in such cases.

Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interference

This study identifies microenvironmental factors driving transcriptional heterogeneity in glioblastomas through spatial transcriptomics, metabolomics, and proteomics.

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory

This study identifies SARS-CoV-2-specific CD8+ T-cell responses, showing their rapid induction, prolonged contraction, and functional memory formation compared to antibody responses.

Vaccine-induced ICOS+CD38+ cTfh are sensitive biosensors of age-related changes in inflammatory pathways

The paper uses transcriptional profiling to show that vaccine-induced ICOS+CD38+ cTfh cells in elderly show inflammation-related gene signatures and age-associated biological changes.