BTK and MMP9 regulate NLRP3 inflammasome-dependent cytokine and NET responses in primary neutrophils.
V. N. C. Leal, F. Bork, J. C. von Guilleaume, C. L. Greve, S. Bugl, B. Danker, Z. A. Bittner, B. Grimbacher, A. Pontillo, A. N. Weber
This paper shows that BTK and MMP-9 negatively regulate NLRP3 inflammasome activity in neutrophils, affecting cytokine and NET release.
bioRxiv · Feb 23, 2024Immunology