Author

F. Bork

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1

Frequent Co-Authors

S. Bugl· 3 shared A. N. Weber· 2 shared C. L. Greve· 2 shared A. N. R. Weber· 1 shared A. Pontillo· 1 shared A. Tondervik· 1 shared B. Danker· 1 shared B. Grimbacher· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

S. Bugl

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Author profile →

3 papers

Recent·Most cited

BTK and MMP9 regulate NLRP3 inflammasome-dependent cytokine and NET responses in primary neutrophils.

V. N. C. Leal, F. Bork, J. C. von Guilleaume, C. L. Greve, S. Bugl, B. Danker, Z. A. Bittner, B. Grimbacher, A. Pontillo, A. N. Weber

This paper shows that BTK and MMP-9 negatively regulate NLRP3 inflammasome activity in neutrophils, affecting cytokine and NET release.

bioRxiv · Feb 23, 2024Immunology

Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs

F. Bork, C. L. Greve, C. Youn, S. Chen, Y. Wang, M. Nasri, J. Focken, J. Scheurer, P. Engels, M. Dubbelaar, K. Hipp, B. Schittek, S. Bugl, M. W. Loeffler, J. Skokowa, , A. N. Weber

This study identifies naRNA as a pre-assembled composite DAMP in neutrophils that drives NET formation and inflammation via TLR8/TLR13, redefining NETs as intentional inflammatory agents.

bioRxiv · Jul 26, 2022 · PreprintImmunology

Transkingdom mechanism of MAMP generation by chitotriosidase (CHIT1) feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing

T.-H. Chang, Y. C. Gloria, M. J. Hellmann, C.-L. Greve, D. Le Roy, T. Roger, F. Bork, S. Bugl, J. Jakob, L. Kasper, B. Hube, S. Pusch, N. Gow, M. Sorlie, A. Tondervik, , A. N. R. Weber

This study identifies CHIT1 as an enzyme that converts fungal chitin into oligomers sensed by TLR2, revealing a mammalian MAMP generation system similar to plants.

bioRxiv · Feb 17, 2022Immunology