Small Cell Lung Cancer Neuroendocrine Subtypes are Associated with Different Immune Microenvironment and Checkpoint Molecule Distribution
D. Dora, C. Rivard, H. Yu, P. Bunn, K. Suda, S. Ren, S. L. Pickard, V. Laszlo, T. Harko, Z. Megyesfalvi, J. Moldvay, F. R. Hirsch, B. Dome, Z. Lohinai
This study shows that NE-low SCLC tumors have more immune cell infiltration and higher expression of IDO and PVR compared to NE-high tumors, suggesting these as potential immunotherapy targets.
bioRxiv · Feb 2, 2020Cancer Biology