H. Yu

Application of machine learning in a rodent malaria model for rapid, accurate, and consistent parasite counts

The paper develops a machine learning tool for automated parasite counting in rodent malaria models, achieving high accuracy and consistency across labs.

Jagged-1+ Tregs Mediate Lymphatic Remodeling in Tumour-Draining Lymph Nodes

This study shows that Jag1-expressing regulatory T cells (Tregs) in tumor-draining lymph nodes (tdLNs) are essential for lymphatic remodeling and niche formation during melanoma progression.

The Effects of Functional Training on Muscle Strength in Athletes: A Meta-Analysis

This study evaluates functional training's impact on athlete muscle strength compared to traditional resistance training, finding moderate to large effects on maximum strength, power, and muscle endurance.

CD74+ fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloid

This study identifies CD74+ fibroblasts as key drivers of stretch-induced keloid progression through proliferation, angiogenesis, and migration.

SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth

This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.

Diversity and ecological potentials of viral assemblages from the seamount sediments of the Northwest Pacific Ocean

The paper analyzes viral diversity in seamount sediments, identifying 78,069 vOTUs and 16 vAMGs, suggesting ecological roles in biogeochemical cycles.

Engineering PEG10 assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

This paper develops ePAC, a cancer vaccine using PEG10-based virus-like particles to deliver neoantigens and adjuvants, showing efficacy in preclinical models.

AMHY and sex determination in egg-laying mammals

This study identifies AMHY as the primary male sex determination gene in monotremes by analyzing its expression and function during sexual differentiation.

Optimised Nanobody-based Quenchbodies for Enhanced Protein Detection

This study optimizes nanobody-based quenchbodies for enhanced protein detection, achieving fluorescence increases of 1.5-2.4-fold and detecting IL-6 down to 2 nM.

A double-negative prostate cancer subtype is vulnerable to SWI/SNF-targeting degrader molecules

This study identifies a SWI/SNF-targeting therapy effective against a double-negative prostate cancer subtype, showing it reduces viability in both AR-dependent and WNT-dependent models.

Flight performance, activity and behaviour of breeding pied flycatchers in the wild, revealed with accelerometers and machine learning

This study uses accelerometers and machine learning to analyze flight behavior in pied flycatchers, finding no significant sex differences in flight activity despite males having higher flight performance potential.

The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice

This study investigates the evolutionary history of cultivated rice and identifies genomic signatures of heterosis in super-hybrid rice varieties.

Global RNA Virome in Wastewater Treatment Plants Reveals Ecological Insights and Human Health Implications

This study analyzes RNA virus diversity in wastewater treatment plants, identifying new viral lineages and their ecological and health implications.

CTAT-LR-fusion: accurate fusion transcript identification from long and short read isoform sequencing at bulk or single cell resolution

CTAT-LR-fusion detects fusion transcripts from long and short read RNA-seq data, improving accuracy in bulk and single cell transcriptomes.

Nodulation Trio in Medicago truncatula: Unveiling the Overlapping Roles of MtLYK2, MtLYK3, and MtLYK2bis

This study investigates the roles of MtLYK2, MtLYK3, and MtLYK2bis in Medicago truncatula nodulation using CRISPR/Cas mutants, finding redundant functions and suggesting a one-receptor model with multiple specificities.

Fingerprint localisation for fine-scale wildlife tracking using automated radio telemetry

This paper develops a radio fingerprinting method for wildlife tracking using automated radio telemetry, showing it outperforms multilateration in accuracy and robustness under challenging conditions.

The Xanthomonas fragariae effector XopK suppresses stomatal immunity by perturbing abscisic acid signaling in strawberry

This study identifies XopK, an effector from Xanthomonas fragariae, which suppresses stomatal immunity by disrupting abscisic acid signaling in strawberries, leading to increased susceptibility to infection.

RNA Splicing Junction Landscape Reveals Abundant Tumor-Specific Transcripts in Human Cancer

This study analyzes RNA splicing junctions in 34,775 samples to identify 29,051 tumor-specific transcripts linked to cancer stemness, poor prognosis, and immunotherapy targets.

Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity

This study shows that neuritin modulates T cell electrical and metabolic states, influencing immune tolerance and immunity.

Age-related RPE Changes in Wildtype C57BL/6J Mice Between 2 and 32 Months

This study evaluates age-related changes in RPE structure and function in C57BL/6J mice, finding increased alpha-catenin expression and immune cell recruitment in aged mice.

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery

This study develops rod-shaped Janus base nanopieces for improved tissue penetration and therapeutics delivery, showing better efficacy than spherical lipid nanoparticles in ovarian cancer models.

Broadly conserved FlgV controls flagellar assembly and Borrelia burgdorferi dissemination in mice

This study identifies FlgV as a conserved flagellar component in Borrelia burgdorferi, showing its role in flagellar assembly and pathogen dissemination in mice.

A General-Purpose Non-invasive Neurotechnology Research Platform

The paper introduces a non-invasive neurotechnology platform with multi-modal sensors and integration into BCI2000, demonstrating its use in sleep monitoring and evoked potentials.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Role of Dusp5 KO on Vascular Properties of Middle Cerebral Artery in Rats

This study examines the structural and mechanical properties of the middle cerebral artery in Dusp5 KO rats, finding limited structural changes but enhanced myogenic tone, suggesting Dusp5's role in hemodynamics and cognition is enzyme-driven.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

This study identifies two double mutations in SARS-CoV-2 3CLpro that confer resistance to the non-covalent inhibitor WU-04 and reveals trade-offs between catalytic activity, thermostability, and drug resistance.

Neurophysiological Features of STN LFP underlying Sleep Fragmentation in Parkinson's Disease

This study identifies STN LFP features, including beta and gamma oscillations and the low-high power ratio, that correlate with sleep fragmentation in Parkinson's disease patients.

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

Olfactory learning in Drosophila requires O-GlcNAcylation of mushroom body ribosomal subunits

This study identifies O-GlcNAcylation of mushroom body ribosomal subunits as essential for olfactory learning in Drosophila, showing that reducing O-GlcNAcylation impairs learning.