S. Ren

Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation

This study identifies Sirt5's role in regulating chondrocyte metabolism and osteoarthritis through lysine malonylation, showing its dysregulation contributes to OA in aging and obesity.

Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease

This study identifies mutation and transcriptional state compatibility in Ph+ ALL MRD, showing that targeting these interactions can overcome BCR::ABL1 independence and improve MRD monitoring.

Human FAM111A inhibits vaccinia virus replication by degrading viral DNA-binding protein I3 and is antagonized by poxvirus host range factor SPI-1

This study identifies FAM111A as a restriction factor for vaccinia virus and MVA, showing it degrades viral DNA-binding protein I3 and is counteracted by SPI-1.

Streamlined regulation of chloroplast development in the liverwort Marchantia polymorpha

The paper investigates chloroplast development regulation in liverwort Marchantia polymorpha, finding that GLK controls chloroplast biogenesis while GATA and SCL have no detectable roles.

Net-shaped DNA nanostructure designed for rapid/sensitive detection and potential inhibition of SARS-CoV-2 virus

The paper designs a DNA nanostructure for rapid, sensitive, and inexpensive detection of SARS-CoV-2 and demonstrates its potential to inhibit viral infection.

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

This study evaluates ALG-097111, a selective SARS-CoV-2 3CLpro inhibitor, showing potent in vitro activity and significant in vivo antiviral effects in Syrian hamsters.

ORF3a mediated-incomplete autophagy facilitates SARS-CoV-2 replication

This study shows that SARS-CoV-2 ORF3a induces incomplete autophagy by interacting with UVRAG, impairing autophagosome maturation and enhancing viral replication.

Necrotizing enterocolitis-induced systemic immune suppression in neonatal preterm pigs

This study shows that necrotizing enterocolitis (NEC) in preterm pigs leads to systemic immune suppression, increasing susceptibility to secondary infections.

A targetable epigenetic vulnerability in PI3K/AKT inhibitor resistant cancers

This study identifies an epigenetic vulnerability in PI3K/AKT inhibitor-resistant cancers, showing that targeting bromodomain or HDAC inhibitors can overcome resistance by modulating histone acetylation at growth factor/receptor gene loci.

Multiple expression assessments of ACE2 and TMPRSS2 SARS-CoV-2 entry molecules in the urinary tract and their associations with clinical manifestations of COVID-19

Small Cell Lung Cancer Neuroendocrine Subtypes are Associated with Different Immune Microenvironment and Checkpoint Molecule Distribution

This study shows that NE-low SCLC tumors have more immune cell infiltration and higher expression of IDO and PVR compared to NE-high tumors, suggesting these as potential immunotherapy targets.

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition

The paper designs a DNA nanostructure that recognizes and inhibits dengue virus through precise spatial arrangement of aptamers, enabling sensitive and rapid sensing and inhibition.

Extensive adaptive immune response of AAVs and Cas proteins in non-human primates

The paper investigates pre-existing adaptive immune responses to CRISPR Cas proteins and AAVs in non-human primates and finds such immunity is普遍存在 regardless of Cas proteins or AAVs.