Validation of a small molecule inhibitor of PDE6D-RAS interaction with potent anti-leukemic effects
S. C. Nunes, S. De Vita, A. Anighoro, F. Autelitano, E. Beaumont, P. Klingbeil, M. McGuinness, B. Duvert, C. Harris, L. Yang, S. P. Pokharel, C.-W. Chen, M. Ermann, D. A. Williams, H. Xu
The paper identifies a small molecule inhibitor of PDE6D-RAS interaction that shows anti-leukemic effects by blocking RAC activation in RAS-mutated cells.
bioRxiv · Mar 14, 2022Cancer Biology