C.-W. Chen

A Sap Peptide Conserved across Flowering Plants Positively Regulates Lignin Biosynthesis, Biomass and Immunity

TIMAHAC: Streamlined Tandem IMAC-HILIC Workflow for Simultaneous and High-Throughput Plant Phosphoproteomics and N-glycoproteomics

TIMAHAC enables high-throughput simultaneous analysis of plant phosphoproteomics and N-glycoproteomics, identifying 1,954 N-glycopeptides and 11,255 phosphopeptides in Arabidopsis under ABA treatment.

Mitochondrial ncRNA LDL-805 declines in alveolar epithelial type 2 cells of chronic obstructive pulmonary disease patients.

This study identifies a human homologue of a mitochondrial noncoding RNA that translocates to the nucleus and enhances mitochondrial bioenergetics in response to cigarette smoke, but its levels decline in chronic obstructive pulmonary disease.

SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells

This study identifies SOD1 as a synthetic lethal target in PPM1D-mutant leukemia cells through CRISPR/Cas9 screening, revealing a dysregulated redox landscape and potential therapeutic strategy.

A Suspension Trapping-Based Sample Preparation Workflow for Sensitive Plant Phosphoproteomics

The paper develops a tandem S-Trap-IMAC method for plant phosphoproteomics, improving coverage and quantification accuracy in Arabidopsis.

Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1

The paper reports cryo-EM structures of PTH1R bound to PTH and PTHrP, revealing molecular mechanisms of hormone recognition and selectivity.

MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

This study shows that MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer by affecting chromatin modifications and gene expression.

Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis

This study shows that loss of DNMT3A causes obesity by disrupting adipogenesis and triggering inflammation in adipose tissue.

Validation of a small molecule inhibitor of PDE6D-RAS interaction with potent anti-leukemic effects

The paper identifies a small molecule inhibitor of PDE6D-RAS interaction that shows anti-leukemic effects by blocking RAC activation in RAS-mutated cells.

Endometrial Gap Junction Expression - Early Indicators of Endometriosis and Integral to Invasiveness

The paper identifies gap junction expression changes in endometrial cells as indicators of endometriosis and shows their role in lesion invasiveness.

Genomic, geographic and temporal distributions of SARS-CoV-2 mutations

This study analyzes the genomic, geographic, and temporal distribution of SARS-CoV-2 mutations using 1,932 genomes, identifying six phylogenetic clusters and a positive correlation between mutation count and case fatality.

DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A

This study shows that DOT1L regulates the senescence-associated secretory phenotype (SASP) through epigenetic control of IL1A expression in oncogene-induced senescence.

ATM Inhibition Synergizes with Fenofibrate in High Grade Serous Ovarian Cancer Cells

This study shows that combining ATM inhibitors with fenofibrate improves treatment in high-grade serous ovarian cancer cells by inducing senescence.

Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition

This study shows that leukemia cell of origin affects apoptotic priming and sensitivity to LSD1 inhibitors, with Evi1 modulating p53 stability and activity.

ATM inhibition drives metabolic adaptation via induction of macropinocytosis

This study shows that ATM inhibition promotes cancer cell survival by increasing macropinocytosis, which can be suppressed by BCAA supplementation.

Characterization of TAG-63 and its role on axonal transport in C. elegans

This study identifies TAG-63 as a neurofilament-like protein in C. elegans and shows its role in axonal transport by interacting with UNC-104 and affecting motor speed and filament stability.

Suppression of p16 increases nucleotide synthesis via mTORC1

This study shows that p16 suppression increases nucleotide synthesis through mTORC1 activation, promoting tumorigenesis by bypassing senescence.

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.

This study shows that SIRT3 activation is required for ovarian cancer cell survival and metastasis by regulating mitochondrial antioxidant defenses and metabolic changes during detachment.