BiophysicsbioRxiv
Design of stimulus-responsive two-state hinge proteins
F. Praetorius, P. J. Y. Leung, M. H. Tessmer…·D. Baker
This paper designs two-state hinge proteins that switch between structural states in response to ligands, demonstrating atomic-level accuracy and tunable kinetics and thermodynamics.
DOI 10.1126/science.adg7731