Author

A. Pillai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 2 Biophysics· 1 Cancer Biology· 1 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Approach:deep learning· 3 Organism:human· 3 Assay:protein structure· 3 Research Focus:cell type annotation· 2 Research Focus:protein design· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Baker· 3 shared A. Broerman· 2 shared A. Idris· 2 shared A. K. Bera· 2 shared A. Kang· 2 shared C. Demakis· 2 shared D. Juergens· 2 shared F. Praetorius· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

D. Baker

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Symmetry facilitated the evolution of specificity and high-order stoichiometry in vertebrate hemoglobin

C. R. Cortez-Romero, J. Lyu, A. Pillai, A. Laganowsky, J. W. Thornton

This study investigates how vertebrate hemoglobin evolved from a homodimeric ancestor to a heterotetramer through simple genetic changes that exploited symmetry in its structure.

bioRxiv · Jul 24, 2024Evolutionary Biology

Frequent transitions in self-assembly across the evolution of a central metabolic enzyme

F. L. Sendker, T. Schlotthauer, C.-N. Mais, Y. K. Lo, M. Girbig, S. Bohn, T. Heimerl, D. Schindler, A. Weinstein, B. P. Metzger, J. W. Thornton, A. Pillai, G. Bange, J. Schuller, G. Hochberg

The paper investigates the evolutionary dynamics of self-assembly in prokaryotic citrate synthases, finding frequent transitions between different assembly types without strong functional consequences.

bioRxiv · Jul 5, 2024Evolutionary Biology

De novo design of diverse small molecule binders and sensors using Shape Complementary Pseudocycles

L. An, M. Said, L. Tran, S. Majumder, I. Goreshnik, G. R. Lee, D. Juergens, J. Dauparas, I. Anishchenko, B. Coventry, A. K. Bera, A. Kang, P. M. Levine, V. Alvarez, A. Pillai, , D. Baker

The paper designs nanomolar binders for diverse small molecules using a pseudocycle-based shape complementarity method, enabling direct conversion into sensing systems.

bioRxiv · Dec 20, 2023 · PreprintBiochemistry

De novo design of allosterically switchable protein assemblies

A. Pillai, A. Idris, A. Philomin, C. Weidle, R. Skotheim, P. J. Y. Leung, A. Broerman, C. Demakis, A. J. Borst, F. Praetorius, D. Baker

This paper designs allosterically switchable protein assemblies using rigid-body coupling of effector-switchable modules, demonstrating cooperative ligand binding and structural changes similar to natural systems.

bioRxiv · Nov 1, 2023Biochemistry

Broad and potent neutralizing mAbs are elicited in vaccinated individuals following Delta/BA.1 breakthrough infection

J. Seow, Z. A. Shalim, C. Graham, S. Kimuda, A. Pillai, T. Lechmere, A. Kurshan, A. Khimji, L. Snell, G. Nebbia, C. Mant, A. Waters, J. Fox, M. H. Malim, K. J. Doores

The paper shows that vaccinated individuals develop broad neutralizing mAbs after Delta/BA.1 infection, but these mAbs are less effective against newer variants.

bioRxiv · Mar 30, 2023 · PreprintImmunology

Design of stimulus-responsive two-state hinge proteins

F. Praetorius, P. J. Y. Leung, M. H. Tessmer, A. Broerman, C. Demakis, A. F. Dishman, A. Pillai, A. Idris, D. Juergens, J. Dauparas, X. Li, P. M. Levine, M. Lamb, R. K. Ballard, S. R. Gerben, , D. Baker

This paper designs two-state hinge proteins that switch between structural states in response to ligands, demonstrating atomic-level accuracy and tunable kinetics and thermodynamics.

bioRxiv · Jan 27, 2023Biophysics

Distinct Mechanisms of Innate and Adaptive Immune Regulation Underlie Poor Oncologic Outcomes Associated with KRAS-TP53 Co-Alteration in Pancreatic Cancer

J. Datta, A. Bianchi, I. De Castro Silva, N. U. Deshpande, L. L. Cao, S. Mehra, S. Singh, C. Rafie, X. Sun, X. Chen, X. Dai, A. Colaprico, P. Sharma, A. R. Dosch, A. Pillai, , N. B. Merchant

bioRxiv · May 1, 2022Cancer Biology

Novel, economically important semi-dwarf and early mutants: Selection and development from Improved White Ponni Rice (Oryza sativa L.)

S. Ramchander, A. P. Leon, J. K. Yasin, V. KK, A. Pillai

The paper identifies early and semi-dwarf mutants of Improved White Ponni rice through gamma-ray mutagenesis and characterizes their genetic and phenotypic traits.

bioRxiv · Dec 18, 2018 · PreprintPlant Biology