Author

A. Broerman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Baker· 3 shared A. Idris· 2 shared A. Pillai· 2 shared C. Demakis· 2 shared F. Praetorius· 2 shared P. J. Y. Leung· 2 shared A. F. Dishman· 1 shared A. J. Borst· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersBiochemistry

D. Baker

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Author profile →

3 papers

Recent·Most cited

De novo design of allosterically switchable protein assemblies

A. Pillai, A. Idris, A. Philomin, C. Weidle, R. Skotheim, P. J. Y. Leung, A. Broerman, C. Demakis, A. J. Borst, F. Praetorius, D. Baker

This paper designs allosterically switchable protein assemblies using rigid-body coupling of effector-switchable modules, demonstrating cooperative ligand binding and structural changes similar to natural systems.

bioRxiv · Nov 1, 2023Biochemistry

Design of stimulus-responsive two-state hinge proteins

F. Praetorius, P. J. Y. Leung, M. H. Tessmer, A. Broerman, C. Demakis, A. F. Dishman, A. Pillai, A. Idris, D. Juergens, J. Dauparas, X. Li, P. M. Levine, M. Lamb, R. K. Ballard, S. R. Gerben, , D. Baker

This paper designs two-state hinge proteins that switch between structural states in response to ligands, demonstrating atomic-level accuracy and tunable kinetics and thermodynamics.

bioRxiv · Jan 27, 2023Biophysics

De novo design of modular peptide binding proteins by superhelical matching

K. Wu, H. Bai, Y.-T. Chang, R. Redler, K. E. McNally, W. Sheffler, T. Brunette, D. R. Hicks, T. E. Morgan, T. J. Stevens, A. Broerman, I. Goreshnik, M. DeWitt, C. M. Chow, Y. Shen, , D. Baker

This paper introduces a method to design modular peptide binding proteins that bind repeating peptide sequences with high specificity and affinity.

bioRxiv · Nov 14, 2022 · PreprintBiochemistry