Identification and targeting of a pan-genotypic influenza A virus RNA structure that mediates packaging and disease.
R. J. Hagey, M. Elazar, S. Tian, E. A. Pham, W. Kladwang, L. Ben-Avi, K. Nguyen, A. Xiong, M. Rabinovich, S. Schaffert, T. Avisar, B. Fram, P. Liu, P. Khatri, J. K. Taubenberger, , J. S. Glenn
This paper identifies a conserved RNA structure in influenza A virus that mediates packaging and disease, showing that targeting it inhibits virus production and reduces disease severity.
bioRxiv · Aug 21, 2021 · PreprintMicrobiology