P. Liu

AMH regulates ovary size by counteracting ovarian follicle cluster effects.

The paper shows AMH limits ovarian follicle overgrowth by counteracting the survival-promoting effect of proximity to large follicles.

An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

Uncovering the hidden RNA virus diversity in Lake Nam Co: evolutionary insights from an extreme high-altitude environment

This study identifies 742 RNA virus species in Lake Nam Co, revealing novel viral groups and evolutionary adaptations in an extreme high-altitude environment.

Chromosome-level genome assembly of autotetraploid Selenicereus megalanthus and gaining genomic insights into the evolution of trait patterning in diploid and polyploid pitaya species

Elevated CO2 alters soybean physiology and defense responses, and has disparate effects on susceptibility to diverse microbial pathogens

This study examines how elevated CO2 affects soybean susceptibility to various pathogens and finds mixed effects on disease outcomes and defense responses.

Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

This study shows that artesunate, EDTA, and colistin work together to fight Salmonella strains resistant to colistin, by damaging cell membranes and inhibiting MCR-1.

A conserved lysine/arginine-rich motif in potyviral 6K1 protein is key in engaging autophagy-mediated self-degradation for completing pepper veinal mottle virus infection

This study identifies a conserved lysine/arginine-rich motif in potyviral 6K1 protein that mediates autophagy-mediated self-degradation, essential for viral infection.

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer

This study shows BET inhibition in liver cancer reduces proliferation by inducing GDH1-dependent glutamine metabolic changes, suggesting a therapeutic strategy combining BET and OXPHOS inhibitors.

NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni

This study identifies NLRP3 and AIM2 inflammasomes as key drivers of pathogenic Th17 responses in Schistosoma mansoni infection, showing their role in promoting inflammation and their counteraction by the IFN-I pathway.

Engineering customized viral receptors for various coronaviruses

This paper develops a method to engineer customized viral receptors (CVRs) for various coronaviruses, enabling infection models for viruses lacking known receptors.

Ubiquitin-mediated stabilization of SlPsbS regulates low night temperature tolerance in tomatoes

This study identifies a ubiquitin-mediated degradation pathway involving SlCV and SlCSN5A that regulates SlPsbS stability under low night temperatures in tomatoes.

Bifidobacterium longum subsp. longum BG-L47 boosts growth and activity of Limosilactobacillus reuteri DSM 17938 and its extracellular membrane vesicles

This paper identifies Bifidobacterium longum subsp. longum BG-L47 as a strain that enhances the growth and activity of Limosilactobacillus reuteri DSM 17938 and demonstrates its safety for consumption.

Sarbecovirus RBD indels and specific residues dictating ACE2 multi-species adaptiveness

This study identifies RBM indel types in sarbecoviruses and their impact on ACE2 receptor usage across species, revealing how specific residues and structural features influence tropism and adaptiveness.

Direct delivery of stabilized Cas-embedded base editors achieves efficient and accurate editing of clinically relevant targets

This study develops stabilized Cas-embedded base editors (sCE_CBEs) that enable efficient and accurate C-to-T editing with minimal off-target effects in hematopoietic stem and progenitor cells.

Mapping the soil microbiome functions shaping wetland methane emissions

The paper maps soil microbiome functions in wetlands to understand methane emissions by analyzing microbial communities and gene expression across spatial and temporal gradients.

Genome-wide CRISPR screen identifies AC9 as a key regulator of ER calcium homeostasis involved in neuronal differentiation.

The paper identifies AC9 as a key regulator of ER calcium homeostasis during neuronal differentiation using CRISPR screening and functional analysis.

Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through multiple mechanisms

This study investigates how N354 glycosylation in the SARS-CoV-2 spike protein affects viral fitness and human adaptation through multiple mechanisms.

Origin and evolutionary trajectories of brown algal sex chromosomes

The paper analyzes brown algal genomes to trace the origin and evolution of U/V sex chromosomes, revealing gene gain-driven evolution and the demise of these systems through hermaphroditism and gene hierarchy shifts.

Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity

The paper identifies FATP2 as a conserved target for preventing starvation-induced liver atrophy by reducing fatty acid uptake in cavefish and other species.

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

This study shows capsaicin directly binds KEAP1 and allosterically activates NRF2, reducing ethanol-induced gastric oxidative damage and suggesting its potential as a novel NRF2 agonist for oxidative stress-related diseases.

Climate and urbanization drive changes in the habitat suitability of Schistosoma mansoni competent snails in Brazil

The paper uses machine learning and remote sensing to analyze 30 years of snail occurrence data in Brazil, showing climate change and urbanization have altered Biomphalaria habitat suitability.

Function-associated scRNA-seq on single lung cancer organoids unravels the immune landscape of tumor parenchyma

The paper uses single-cell RNA sequencing on lung cancer organoids to study the tumor immune microenvironment and identifies key genes and T cell activity factors related to immunotherapy response.

ERLIN1 may be involved in DHRS1-induced Change in Lipid Droplet Morphology in HeLa Cell

This study shows DHRS1 localizes to lipid droplets in HeLa cells and alters their morphology, with ERLIN1 potentially regulating DHRS1's effect on lipid droplet size and triacylglycerol levels.

Multifrequency control of Faraday wave bioassembly for constructing multiscale hPSC-derived neuronal networks

This paper introduces a multifrequency Faraday wave bioassembly technique to create multiscale neuronal networks from hPSCs, demonstrating spontaneous neuroelectrical activity.

Atlas of Fshr Expression from Novel Reporter Mice

This paper develops Fshr-ZsGreen knockin reporter mice to study FSHR expression in vivo, revealing novel extragonadal expression patterns and expanding the known physiological roles of the FSH-FSHR pathway.

Spatiotemporal Profiling Unveiling the Cellular Organization Patterns and Local Protumoral Immune Microenvironment Remodeling in Early Lung Adenocarcinoma Progression

The paper uses spatial transcriptomics and single-cell RNA sequencing to identify cellular organization patterns and immune microenvironment changes in early lung adenocarcinoma progression.

Addressing the dNTP bottleneck restricting prime editing activity

This study identifies mutations to improve prime editing efficiency in low-dNTP environments by enhancing MMLV-reverse transcriptase and reducing SAMHD1 activity.

M1 Macrophage-Related Genes Model for NSCLC Immunotherapy Response Prediction

This study develops a model using M1 macrophage-related genes to predict immunotherapy response and prognosis in advanced NSCLC patients.

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

The paper identifies two European bat MERS-related coronaviruses that use ACE2 as their receptor, revealing a distinct binding mode and host tropism determinants.