Defective cytoskeletal dynamics underlies the essential role of MRTF-SRF in IL-2 delivery to CD8+ T cells during infectious challenge
D. Maurice, P. Costello, F. Gualdrini, B. Frederico, R. Treisman
This study shows that MRTF-SRF is essential for CD8+ T cell expansion and memory persistence during infection by regulating cytoskeletal dynamics and IL-2 signaling.
bioRxiv · Aug 26, 2023 · PreprintImmunology