CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptors
T. Kyung, K. S. Gordon, C. R. Perez, P. V. Holec, A. Ramos, A. Q. Zhang, Y. Liu, C. Koch, A. Starchenko, B. Joughin, D. A. Lauffenburger, D. J. Irvine, M. T. Hemann, M. E. Birnbaum
The paper develops a library-based platform to identify optimized chimeric antigen receptors (CARs) with improved anti-tumor functions through high-throughput screening of diverse signaling domains.
bioRxiv · Jul 9, 2021Immunology