A. Ramos

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds

This study uses CRISPR to eliminate the FOXL2 c.402C>G mutation in granulosa tumor cells, reducing malignancy and identifying anti-tumoral compounds.

Elaboration of the Homer1 Recognition Landscape Reveals Incomplete Divergence of Paralogous EVH1 Domains

The paper identifies sequences that bind to Homer1 EVH1 domain through proteome screening, revealing overlapping binding preferences with Ena/VASP EVH1 domains and suggesting incomplete divergence from a common ancestor.

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

Hormone levels increase in response to video playback in the Siamese fighting fish

This study shows that male Siamese fighting fish exhibit similar aggressive behaviors and endocrine responses to live and video playback stimuli, supporting the use of video playback in aggression research.

Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening.

This study identifies leukemia-intrinsic resistance mechanisms to CAR-T therapy through in vivo CRISPR screening in a murine B-ALL model, revealing IFNγ/JAK/STAT and antigen processing pathways as key mediators.

CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptors

The paper develops a library-based platform to identify optimized chimeric antigen receptors (CARs) with improved anti-tumor functions through high-throughput screening of diverse signaling domains.

Immune profiling of gliomas reveals a connection with Tau function and the tumor vasculature.

The paper profiles immune cells in gliomas, identifying two immune profiles in IDH1/2 wild-type tumors and linking immune content to vascular alterations and Tau expression.