Necessary Role of Acute Ceramide Formation in The Human Microvascular Endothelium During Health and Disease
G. SenthilKumar, B. Katunaric, Z. Zirgibel, B. Lindemer, M. J. Jaramillo-Torres, H. Bordas-Murphy, M. E. Schulz, P. J. Pearson, J. K. Freed
This study shows that acute ceramide formation via NSmase is essential for NO signaling in human microvascular endothelium, with distinct mechanisms in healthy individuals and CAD patients.
Circulation Research · Jan 5, 2024Peer-reviewedPhysiology