Effect of psilocybin on marble-burying in ICR mice: Role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder
S. Singh, A. Botvinnik, O. Shahar, G. Wolf, C. Yakobi, M. Saban, A. Salama, A. Lotan, B. Lerer, T. Lifschytz
This study investigates psilocybin's effect on marble-burying in mice, finding that 5-HT1A receptors mediate some effects but not the primary action, and that buspirone may block psychedelic effects without affecting anti-obsessional effects.
bioRxiv · Jul 13, 2022Pharmacology & Toxicology