Mono-ADP-ribosylation by ARTD10 restricts Chikungunya virus replication by interfering with the proteolytic activity of nsP2
S. Krieg, F. Pott, L. Eckei, M. Verheirstaeten, M. Buetepage, B. Lippok, C. Goffinet, B. Luescher, P. Verheugd
This study identifies ARTD10 and ARTD12 as antiviral factors that inhibit CHIKV replication by MARylating nsP2, thereby blocking its protease activity, which is counteracted by the viral nsP3 macrodomain.
bioRxiv · Jan 7, 2020 · PreprintMicrobiology