C. Goffinet

Neural Network-Assisted Humanization of COVID-19 Hamster scRNAseq Data Reveals Matching Severity States in Human Disease

This paper uses neural networks to match disease states between human and hamster COVID-19 scRNAseq data, finding similar cellular responses in specific cell types across species.

Single-cell-resolved interspecies comparison identifies a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

The paper compares single-cell RNA-seq data from hamster and human COVID-19 samples to identify a shared inflammatory axis and a neutrophil-endothelial program associated with severe disease.

HIV-1 infection causes depletion of monocytic cells through a non-canonical cell death pathway

This study shows HIV-1 infection causes monocytic cell death via a non-canonical pathway independent of nucleic acid sensing or IFN signaling, requiring viral gene products and occurring after integration.

Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonism

This study shows JQ-1 inhibits SARS-CoV-2 replication via NRF-2 activation but is counteracted by viral antagonism, leading to transient antiviral effects.

SARS-CoV-2 entry route impacts a range of downstream viral and cellular processes

This study shows that SARS-CoV-2 entry via TMPRSS2 or endolysosomal cathepsins affects viral replication, immune response, and genome evolution.

A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants

This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.

Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses

The paper shows that non-productive exposure of PBMCs to SARS-CoV-2 triggers JAK/STAT-dependent innate immune responses in monocytes, similar to those seen in mild COVID-19.

In contrast to TH2-biased approaches, TH1 COVID-19 vaccines protect Syrian hamsters from severe disease in the absence of dexamethasone-treatable vaccine-associated enhanced respiratory pathology

This study compares TH1 and TH2-biased vaccines in Syrian hamsters, showing that TH1 vaccines prevent severe disease without inducing VAERD, while TH2 vaccines cause VAERD through eosinophil recruitment and TH2 cytokine upregulation.

Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line

The paper shows that B.1.1.7 and B.1.617.2 SARS-CoV-2 variants have a replication advantage over B.1 in ACE2-deficient lung cells, suggesting reliance on alternative cellular factors.

A base-line cellular antiviral state is maintained by cGAS and its most frequent naturally occurring variant rs610913

This study shows that the cGAS variant rs610913 maintains a baseline antiviral state, slightly altering susceptibility to viral infections without gross phenotypic differences.

A realistic touch-transfer method reveals low risk of transmission for SARS-CoV-2 by contaminated coins and bank notes

This study assesses the risk of SARS-CoV-2 transmission via contaminated coins and banknotes using a novel touch transfer method and shows it is unlikely under typical conditions.

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.

Human IFITM3 restricts Chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction

This study shows IFITM3 restricts CHIKV and MAYV infection and is counteracted by these viruses, with a variant showing similar antiviral activity to wild-type.

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition

This study shows that IFITM proteins are required for SARS-CoV-2 infection and can be targeted to inhibit viral entry and replication.

Single-cell transcriptomic analysis of antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblasts

The paper uses single-cell RNA-seq to analyze antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblasts, identifying interferon-stimulated genes and immune-related pathways.

Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity

This study shows that type I interferons can enhance NK cell killing of HIV-1-reactivating T-cells despite HDACi-induced immune dysregulation, suggesting a potential strategy to improve shock-and-kill approaches.

Mono-ADP-ribosylation by ARTD10 restricts Chikungunya virus replication by interfering with the proteolytic activity of nsP2

This study identifies ARTD10 and ARTD12 as antiviral factors that inhibit CHIKV replication by MARylating nsP2, thereby blocking its protease activity, which is counteracted by the viral nsP3 macrodomain.