Author

B. Luescher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Ecology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Ozgul· 1 shared B. Lippok· 1 shared B. R. Schmidt· 1 shared C. Goffinet· 1 shared D. Schmocker· 1 shared F. Pott· 1 shared G. Rossetti· 1 shared H. Recher· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperEcology

A. Ozgul

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Four decades of phenology in an alpine amphibian: trends, stasis, and climatic drivers

O. Lenzi, K. Grossenbacher, S. Zumbach, B. Luescher, S. Althaus, D. Schmocker, H. Recher, M. Thoma, A. Ozgul, B. R. Schmidt

This study examines phenological shifts in an alpine toad population over 39 years, finding earlier breeding linked to climate factors but with limited individual variation.

bioRxiv · Aug 16, 2022Ecology

An Enhanced Sampling Approach to the Induced Fit Docking Problem in Protein-Ligand Binding: the case of mono-ADP-ribosylation hydrolases inhibitors

Q. Zhao, R. Capelli, P. Carloni, B. Luescher, J. Li, G. Rossetti

The paper introduces an enhanced sampling method for protein-ligand binding with induced fit, validated on ADPr and MacroD1/MacroD2 complexes, showing accurate free energy predictions and structural changes.

bioRxiv · May 8, 2021Biochemistry

Mono-ADP-ribosylation by ARTD10 restricts Chikungunya virus replication by interfering with the proteolytic activity of nsP2

S. Krieg, F. Pott, L. Eckei, M. Verheirstaeten, M. Buetepage, B. Lippok, C. Goffinet, B. Luescher, P. Verheugd

This study identifies ARTD10 and ARTD12 as antiviral factors that inhibit CHIKV replication by MARylating nsP2, thereby blocking its protease activity, which is counteracted by the viral nsP3 macrodomain.

bioRxiv · Jan 7, 2020 · PreprintMicrobiology