Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis
P. Ortega Gonzalez, G. M. Taylor, R. Jangra, R. Tenorio Vela, I. Fernandez de Castro Martin, B. Mainou, R. Orchard, C. B. Wilen, P. H. Brigleb, J. Sojati, K. Chandran, C. Risco, T. S. Dermody
This study identifies NPC1 and endosomal cholesterol homeostasis as critical for reovirus penetration into the cytoplasm, but not for attachment, internalization, or disassembly.
bioRxiv · Sep 27, 2021 · PreprintCell Biology