Author

C. Risco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

B. Clotet· 3 shared D. Perez-Zsolt· 3 shared J. Segales· 3 shared J. Vergara-Alert· 3 shared M. Sachse· 3 shared N. Izquierdo-Useros· 3 shared D. Raich-Regue· 2 shared J. Blanco· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

B. Clotet

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Beta-Cyclodextrins as affordable antivirals to treat coronavirus infection

D. Raich-Regue, R. Tenorio, I. Fernandez-de-Castro, D. Perez-Zsolt, J. Munoz-Basagoiti, M. Sachse, S. Fernandez-Sanchez, M. Gallemi, P. Ortega-Gonzalez, A. Fernandez-Oliva, J. Gabaldon, E. Nunez-Delicado, J. Casas, F. Tarres, J. Vergara-Alert, , C. Risco

The paper identifies beta-cyclodextrins as effective and affordable antivirals against SARS-CoV-2 and other coronaviruses through molecular modeling and in vitro testing.

bioRxiv · Nov 16, 2022Microbiology

Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming

B. Soler Palacios, R. Villares, P. Lucas, J. M. Rodriguez Frade, A. Cayuela, J. G. Piccirillo, D. Delgado Gestoso, C. Risco, F. Corrales, C. O. S. Sorzano, N. Martinez, J. J. Conesa, F. J. Iborra, M. Mellado

This study shows growth hormone remodels mitochondrial structure and promotes metabolic reprogramming in inflammatory macrophages.

bioRxiv · Aug 22, 2022Immunology

Unraveling the antiviral activity of plitidepsin by subcellular and morphological analysis

M. Sachse, R. Tenorio, I. Fernandez de Castro, J. Munoz-Basagoiti, D. Perez-Zsolt, D. Raich-Regue, J. Rodo, A. Losada, P. Aviles, C. Cuevas, R. Paredes, J. Segales, B. Clotet, J. Vergara-Alert, N. Izquierdo-Useros, C. Risco

This study uses electron microscopy to show plitidepsin blocks SARS-CoV-2 replication organelles and virus morphogenesis.

bioRxiv · Dec 16, 2021Microbiology

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis

P. Ortega Gonzalez, G. M. Taylor, R. Jangra, R. Tenorio Vela, I. Fernandez de Castro Martin, B. Mainou, R. Orchard, C. B. Wilen, P. H. Brigleb, J. Sojati, K. Chandran, C. Risco, T. S. Dermody

This study identifies NPC1 and endosomal cholesterol homeostasis as critical for reovirus penetration into the cytoplasm, but not for attachment, internalization, or disassembly.

bioRxiv · Sep 27, 2021 · PreprintCell Biology

Siglec-1 on dendritic cells mediates SARS-CoV-2 trans-infection of target cells while on macrophages triggers proinflammatory responses

D. Perez-Zsolt, J. Munoz Basagoiti, J. Rodo, M. Elousa, D. Raich Regue, C. Risco, M. Sachse, M. Pino, S. Gumber, M. Paiardini, J. Chojnacki, I. Erkizia, X. Muniz, E. Ballana, E. Riveira Munoz, , N. Izquierdo-Useros

This study shows Siglec-1 on APCs mediates SARS-CoV-2 trans-infection and triggers proinflammatory responses, suggesting it as a potential therapeutic target.

bioRxiv · May 11, 2021 · PreprintMicrobiology