Multi-Species Phenotypic Screening across Disease Models of Mucolipidosis Type IV
A. Hadjikyriacou, S. Iyer, J. D. Mast, N. DiPrimio, J. Concannon, J. Ketterman, F. Sigoillot, T. P. Rodriguez, F. S. Sam, H. Tsang, M. Prangley, J. Bilen, K. Murthy, T. A. Hartl, C. Antczak, , S. M. Canham
The paper screens a compound library across invertebrate and human models of mucolipidosis IV to identify conserved disease modifiers, finding cyclin-dependent kinase inhibition as a potential therapeutic strategy.
bioRxiv · Mar 5, 2021 · PreprintCell Biology