S. Iyer

Calcium Sulfate Microparticle Size Modification for Improved Alginate Hydrogel Fabrication and Its Application in 3D Cell Culture

The paper shows that ball-milled calcium sulfate microparticles improve alginate hydrogel fabrication by creating more stable suspensions, leading to homogeneous gels with consistent mechanical properties for 3D cell culture.

Robust acidic pH and digestive enzyme stability of anti-SarsCov2 IgY antibodies: Implications for treatment of viral transmission thru gastrointestinal, ocular, nasal and skin tissues

The paper evaluates the stability of anti-SARS-CoV-2 IgY antibodies at acidic pH and against trypsin digestion, supporting their use in treating viral transmission through acidic environments.

Targeted neutralizing IgY antibodies against SGLT1 glucose transporter reduce glucose uptake and improve glycemic profile in vivo

An Anti-diabetic Nutraceutical enhances muscle cell glucose uptake of cardiometabolic drugs

The paper tests an anti-diabetic nutraceutical's ability to enhance glucose uptake in muscle cells when combined with cardiometabolic drugs, showing potential for improved glucose control.

Profiling extracellular vesicles in circulation enables the early detection of ovarian cancer

This study develops an extracellular vesicle-based test to detect early-stage high-grade serous ovarian cancer with high sensitivity and specificity using markers identified from murine models and validated in a human pilot study.

Salivary Glands treated with AAV vectors encoding PYY and exendin-4 impact upon taste perception and body mass accumulation in mice.

This study investigates the impact of AAV-mediated overexpression of PYY and exendin-4 in salivary glands on taste perception and body mass in mice, finding reduced body mass accumulation and altered taste responsiveness.

Suppression of insulin stimulated muscle glucose uptake by non-caloric sweetener sucralose and its reversal by an antidiabetic nutraceutical supplement

The paper investigates how non-caloric sweeteners like sucralose affect muscle glucose uptake and shows that a nutraceutical can reverse this effect.

Nutraceutical supplement targeting multiple molecular steps synergistically enhances muscle glucose uptake and improves in vivo oral glucose disposal

This study shows a combination of vitamins improves glucose uptake and disposal in pre-diabetes and type 2 diabetes through multiple molecular targets.

Immunomodulatory effect of mycobacterial outer membrane vesicles coated nanoparticles

This study develops OMV-AuNP as a stabilized TB vaccine candidate showing enhanced immune activation through TLR2 and TLR4.

A 3-Dimensional bioprinted human gut-liver axis model for studying Alcoholic Liver Disease

This study develops a 3D bioprinted gut-liver axis model to investigate how Cytolysin and ethanol together cause intestinal damage in Alcoholic Liver Disease.

Differential Activity of Repurposed Drugs as Receptor Binding Domain Antagonists for Omicron and Native Strains of SarsCov2

The paper tests repurposed drugs as antagonists of SARS-CoV-2 RBD binding, finding that iodine-containing drugs are ineffective against Omicron.

Edible formulations of chicken egg derived IgY antibodies neutralize SarsCoV2 Omicron RBD binding to human ACE2

This study develops edible IgY antibodies from chicken eggs that neutralize Omicron RBD binding to human ACE2 and formulates them into beverages for oral use.

Extracellular Matrix protein gelatin provides higher expansion, reduces size heterogeneity, and maintains cell stiffness in a long-term culture of mesenchymal stem cells.

This study shows that gelatin-coated plates support better proliferation, reduced size heterogeneity, and maintained cell stiffness in long-term mesenchymal stem cell culture compared to other ECM proteins.

Preparation of ingestible antibodies to neutralize the binding of SarsCoV2 RBD (receptor binding domain) to human ACE2 Receptor

This study produces chicken-derived IgY antibodies against SARS-CoV2 RBD to neutralize ACE2 binding, effective against the delta variant, and proposes their use as ingestible passive immunotherapy.

Opportunistic gut sampling indicates differential diet and plastic ingestion risk in Indian dugongs

The paper analyzes gut contents of stranded Indian dugongs to compare seagrass diet and plastic ingestion risk between Tamil Nadu and Gujarat.

Immune microenvironment subtypes and association with tumor cell mutations and antigen expression in follicular lymphoma.

The paper identifies immune microenvironment subtypes in follicular lymphoma linked to tumor mutations and antigen expression, informing potential immunotherapeutic strategies.

Multi-Species Phenotypic Screening across Disease Models of Mucolipidosis Type IV

The paper screens a compound library across invertebrate and human models of mucolipidosis IV to identify conserved disease modifiers, finding cyclin-dependent kinase inhibition as a potential therapeutic strategy.

Proximal and Distal Nephron-specific Adaptation to Furosemide

This study investigates how furosemide induces distinct adaptive responses in proximal and distal nephron segments, revealing mechanisms of diuretic resistance and tubular remodeling.

In vivo genetic screen identifies a SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia

The paper identifies SLC5A3-dependent myo-inositol auxotrophy in AML through genetic screening and shows synthetic lethality between ISYNA1 and SLC5A3.

The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.

Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer

This paper develops a genetically defined, syngeneic organoid platform for ovarian cancer to evaluate combination therapies and finds genotype-specific responses to immunotherapy and chemotherapy.

Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin

This study examines how structural stability of tropomyosins affects their endolysosomal degradation and T-cell reactivity across different invertebrate sources.

The macrophage-expressed gene (mpeg) 1 identifies a subpopulation of B cells in the adult zebrafish

The paper shows that mpeg1.1 labels B cells in adult zebrafish, not just macrophages, suggesting previously identified irf8-independent macrophages may actually be B lymphocytes.

Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG

This paper identifies epalrestat, an existing drug, as a PMM2 enzyme activator for PMM2-CDG, showing it improves enzyme activity in patient fibroblasts.

Drug screens of NGLY1 Deficiency worm and fly models reveal catecholamine, NRF2 and anti-inflammatory pathway activation as potential clinical approaches

The paper identifies drug candidates that rescue growth in NGLY1-deficient worm and fly models by targeting NRF2, anti-inflammatory pathways, and catecholamine signaling.

Molecularly distinct models of zebrafish Myc-induced B cell leukemia

The paper compares two zebrafish B cell leukemia models driven by murine or human c-MYC, finding distinct lineage origins and molecular pathway signatures.