K. Murthy

Preferential transport of synaptic vesicles across neuronal branches is regulated by the levels of the anterograde motor UNC-104/KIF1A

The paper shows that UNC-104/KIF1A levels regulate synaptic vesicle transport preference in C. elegans neurons, favoring synaptic branches over asynaptic ends.

Cargo crowding, stationary clusters and dynamical reservoirs in axonal transport

This study develops a simulation model of axonal transport in C. elegans touch neurons, showing that stationary vesicle clusters act as dynamic reservoirs that can be regulated to control cargo flux.

Multi-Species Phenotypic Screening across Disease Models of Mucolipidosis Type IV

The paper screens a compound library across invertebrate and human models of mucolipidosis IV to identify conserved disease modifiers, finding cyclin-dependent kinase inhibition as a potential therapeutic strategy.

Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG

This paper identifies epalrestat, an existing drug, as a PMM2 enzyme activator for PMM2-CDG, showing it improves enzyme activity in patient fibroblasts.

Cargo crowding at actin-rich regions along axons causes local traffic jams in neurons

The paper shows that cargo stalling at actin-rich regions in axons causes local traffic jams, which function as reservoirs to maintain robust cargo flow in neurons.