Escaping antibody responses to bacteriolytic enzymes Pal and Cpl-1 by epitope scanning and engineering
M. A. Harhala, K. Gembara, I. Rybicka, Z. Kazmierczak, P. Miernikiewicz, J. Majewska, W. Budziar, A. Nasulewicz-Goldeman, D. C. Nelson, B. Owczarek, K. Dabrowska
The paper engineers bacteriolytic enzymes to escape antibody responses by modifying immunogenic epitopes, showing increased antibacterial activity and reduced cross-neutralization.
bioRxiv · Oct 6, 2022 · PreprintBioengineering