D. C. Nelson

Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression

This study shows that inhibiting stromal Class I HDACs reduces pancreatic cancer progression by targeting desmoplastic and pro-tumorigenic programs in cancer-associated fibroblasts.

Escaping antibody responses to bacteriolytic enzymes Pal and Cpl-1 by epitope scanning and engineering

The paper engineers bacteriolytic enzymes to escape antibody responses by modifying immunogenic epitopes, showing increased antibacterial activity and reduced cross-neutralization.

An Orobanche cernua x Orobanche cumana segregating population provides insight into the regulation of germination specificity in a parasitic plant

The paper analyzes a segregating population of Orobanche species to investigate the genetic basis of germination specificity in parasitic plants.

Activation Mechanism of Strigolactone Receptors And Its Impact On Ligand Selectivity Between Host And Parasitic Plants

This study uses molecular dynamics simulations to show that ShHTL7 and AtD14 adopt active conformations without ligand, but ShHTL7 has a higher population in the inactive state due to sequence differences affecting binding pocket closure.

Strigolactones are chemoattractants for host tropism in Orobanchaceae parasitic plants

This study identifies strigolactones as chemoattractants guiding host tropism in parasitic Orobanchaceae plants.

Thermal characterization and interaction of the subunits from the multimeric bacteriophage endolysin PlyC

This study investigates the thermal stability and subunit interactions of PlyC, a multimeric endolysin, revealing how subunit unfolding affects enzyme activity and reconstitution.

A KARRIKIN INSENSITIVE2 paralog in lettuce mediates highly sensitive germination responses to karrikinolide

This study identifies LsKAI2b as the lettuce receptor mediating sensitive KAR1 germination responses, with specific residues determining ligand specificity.

Rapid analysis of strigolactone receptor activity in a Nicotiana benthamiana dwarf14 mutant

The paper evaluates AtD14 mutants' ability to degrade AtSMXL7 in N. benthamiana D14 mutants, showing that catalytic activity is required for this function.

Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin

This study identifies the molecular interaction between the PlyCB CBD of the PlyC endolysin and the pRha backbone of Group A Streptococcus and Streptococcus mutans cell wall polysaccharides.

Role of substrate recognition in modulating strigolactone receptor selectivity in witchweed.

This study investigates how substrate recognition modulates strigolactone receptor selectivity in witchweed using molecular dynamics simulations and structural analysis.

A series of dual-reporter vectors for ratiometric analysis of protein abundance in plants

The paper introduces a set of dual-reporter vectors for ratiometric analysis of protein abundance in plants, showing that mScarlet-I and luciferases provide high signal-to-noise ratios for transient expression studies.