Cell BiologybioRxivPreprint
p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells
J. Majewska, A. Agrawal, A. Mayo…·V. Krizhanovsky
This study identifies p16-dependent upregulation of PD-L1 in senescent cells as a mechanism to evade immune clearance, showing that anti-PD-L1 treatment can eliminate these cells.
DOI 10.1101/2023.01.30.524522