Effectors enabling adaptation to mitochondrial complex I loss in Hurthle cell carcinoma
R. K. Gopal, V. R. Vantaku, A. Panda, B. Reimer, S. Rath, T.-L. To, A. S. Fisch, M. Cetinbas, M. Livneh, M. J. Calcaterra, B. Gigliotti, K. Pierce, C. B. Clish, D. Dias-Santagata, P. M. Sadow, , V. Mootha
This study identifies molecular effectors in Hurthle cell carcinoma linked to mitochondrial complex I loss, highlighting lipid peroxide scavenging as a therapeutic vulnerability.
bioRxiv · Aug 16, 2022Cancer Biology