YTHDC1 m6A-dependent and m6A-independent functions converge to preserve DNA damage response.
D. Elvira-Blazquez, J. Fernandez-Justel, A. Arcas, L. Statello, E. Goni, J. Gonzalez, B. Ricci, S. Zaccara, I. Raimondi, M. Huarte
This study identifies YTHDC1 as a master regulator of the p53 response through m6A-dependent and -independent mechanisms that affect transcriptional elongation and genomic stability.
bioRxiv · Mar 25, 2024Cancer Biology