J. Gonzalez

ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers

This study shows ZNF397 loss leads to TET2-driven epigenetic changes, lineage plasticity, and resistance to AR-targeted therapies in AR-dependent cancers, with TET2 inhibitors reversing resistance.

Transposable elements identify previously overlooked regions undergoing parallel evolution in response to diverse selective pressures

This study identifies transposable elements (TEs) as previously overlooked targets of selection in Drosophila melanogaster E&R studies, showing their replicability is similar or higher than SNPs.

YTHDC1 m6A-dependent and m6A-independent functions converge to preserve DNA damage response.

This study identifies YTHDC1 as a master regulator of the p53 response through m6A-dependent and -independent mechanisms that affect transcriptional elongation and genomic stability.

A lncRNA-mediated metabolic rewiring of cell senescence

This study identifies sin-lncRNA, a long non-coding RNA that regulates mitochondrial metabolism during cellular senescence by modulating oxidative phosphorylation and DLST localization.

Seasonally increasing parasite load is associated with microbiome dysbiosis in wild bumblebees

This study examines microbiome diversity in wild bumblebees and finds seasonal increases in parasite load linked to microbiome dysbiosis.

The epigenetics effects of transposable elements are context dependent and not restricted to gene silencing

This study examines how transposable elements (TEs) affect histone marks and gene expression in Drosophila, showing context-dependent epigenetic effects beyond gene silencing.

Fast and efficient root phenotyping via pose estimation

This paper introduces a segmentation-free root phenotyping method using pose estimation, showing high accuracy and efficiency compared to segmentation-based approaches.

Transposons contribute to the functional diversification of the head, gut, and ovary transcriptomes across Drosophila natural strains

The paper identifies gene-TE chimeras in head, gut, and ovary transcriptomes of Drosophila natural strains, finding they contribute significantly to gene expression and protein domains.

Piroplasm parasites (Apicomplexa: Piroplasmida) in northeastern populations of the invasive Asian longhorned tick, Haemaphysalis longicornis Neumann (Ixodida: Ixodidae), in the United States

The paper identifies multiple piroplasm parasites in the invasive Asian longhorned tick in the US, including undescribed species and potential human pathogens.

The Nbeta motif of NaTrxh directs secretion as an endoplasmic reticulum transit peptide and variations might result in different cellular targeting

The paper identifies the N{beta} motif as a secretion signal in NaTrxh, a plant thioredoxin lacking a conventional signal peptide, and shows its role in endoplasmic reticulum translocation and protein localization prediction.

Neo-functionalization in Saccharomyces cerevisiae: A Novel Nrg1-Rtg3 chimeric transcriptional modulator is essential to maintain mitochondrial DNA integrity

The paper identifies a chimeric Nrg1/Rtg3 regulator in yeast that is essential for maintaining mitochondrial DNA integrity, showing that its absence leads to irreversible mitochondrial DNA damage.

Ticks (Acari: Ixodida) on synanthropic small and medium-sized mammals in areas of the northeastern United States infested with the Asian longhorned tick, Haemaphysalis longicornis

This study identifies the primary hosts of the invasive Asian longhorned tick in New Jersey, finding it preferentially feeds on larger mammals and is highly abundant, raising concerns about its role in disease transmission.

IκBα controls dormancy induction in Hematopoietic stem cell development via retinoic acid

This study shows that IκBα regulates hematopoietic stem cell (HSC) dormancy by controlling retinoic acid signaling during development.

Population-scale long-read sequencing uncovers transposable elements contributing to gene expression variation and associated with adaptive signatures in Drosophila melanogaster

The paper uses long-read sequencing to analyze transposable element variation in Drosophila melanogaster populations, showing increased detection rates and associations with gene expression and adaptive traits.

Basal and stress-induced expression changes consistent with water loss reduction explain desiccation tolerance of natural Drosophila melanogaster populations

The paper identifies gene expression and physiological differences in Drosophila melanogaster populations that correlate with desiccation tolerance, highlighting the role of tRNA-derived small RNAs in stress response.

The interplay between developmental stage and environment determines the adaptive effect of a natural transposable element insertion

This study investigates how a transposable element insertion in Drosophila melanogaster affects gene expression and survival under different developmental stages and environmental conditions.

JAK-STAT Signaling Enables Lineage Plasticity-driven AR Targeted Therapy Resistance

The paper identifies JAK-STAT signaling as a key driver of lineage plasticity-driven resistance to AR targeted therapy in prostate cancer using integrated transcriptomic and scRNA-Seq analysis.

Detection of velogenic avian paramyxoviruses in rock doves in New York City, New York

The paper screens wild birds in NYC for APMV-1, identifies two isolates, and classifies them into genotype VI, highlighting their potential role in NDV outbreaks.

The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors

This study identifies genetic and environmental factors shaping copper tolerance in Drosophila by analyzing natural population variation and functional gene responses.

Regulatory regions in natural transposable element insertions drive interindividual differences in response to immune challenges in Drosophila

The paper identifies transposable element insertions affecting immune gene expression in Drosophila and shows some increase survival to infection.

Chemotherapy induces a YAP1-dependent fetal conversion to human Colorectal Cancer cells that is predictive of poor patient outcome

The paper shows that sublethal chemotherapy induces a YAP1-dependent fetal phenotype in colorectal cancer cells, which predicts poor patient outcomes.

Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila

The paper identifies parallel seasonal allele frequency shifts in Drosophila melanogaster across North America and Europe, linking environmental conditions to genomic responses to selection.

The discovery, distribution and diversity of DNA viruses associated with Drosophila melanogaster in Europe

The paper identifies and characterizes DNA viruses in Drosophila melanogaster across Europe, revealing new viral lineages and prevalence patterns.

Humoral response to SARS-CoV-2 by healthy and sick dogs during COVID-19 pandemic in Spain.

The paper investigates the humoral response to SARS-CoV-2 in healthy and sick dogs in Spain, finding IgG antibodies without RT-qPCR confirmation, suggesting possible exposure without active infection.

Identification of a long non-coding RNA regulator of liver carcinoma cell survival

The paper identifies a long non-coding RNA, ASTILCS, critical for HCC cell survival and overexpressed in patient tumors.

The loss of the pyoverdine secondary receptor in Pseudomonas aeruginosa results in a fitter strain suitable for population invasion

This study shows that deleting the pyoverdine secondary receptor FpvB in Pseudomonas aeruginosa creates a fitter strain that outcompetes wildtype in structured environments under antibiotic stress.

The first fossil skull of an anteater (Vermilingua, Myrmecophagidae) from northern South America, a taxonomic reassessment of Neotamandua and a discussion of the myrmecophagid diversification

The paper describes a new myrmecophagid genus and species from the Miocene of Colombia, revises the taxonomy of Neotamandua, and proposes a model for the diversification of anteaters.

Genomic adaptations to aquatic and aerial life in mayflies and the origin of wings in insects

This study analyzes the genome and gene expression of mayflies to uncover genomic adaptations related to aquatic and aerial life and the origin of wings in insects.

Applying Nanopore sequencing to a One-Health scenario for colistin resistance transmission among pigs, cows and the farmer

This study uses Nanopore sequencing to analyze colistin resistance genes and other antibiotic resistance genes in pigs, cows, and farmers, identifying genetic contexts and transmission risks.

Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese.

This study shows that exercising before nutrient intake increases lipid utilization and improves insulin sensitivity in overweight or obese men over 6 weeks.