Detection of low numbers of bacterial cells in pharmaceutical drug product using Raman Spectroscopy and PLS-DA multivariate analysis.
R. A. Grosso, A. R. Walther, E. Brunbech, A. Sorensen, B. Schebye, K. E. Olsen, H. Qu, M. A. Hedegaard, E. C. Arnspang
This study detects bacterial contamination in drug products below 10 CFU/ml using Raman spectroscopy and PLS-DA, achieving 99% accuracy.
bioRxiv · Apr 26, 2022Bioengineering