Author

H. Qu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Bioengineering· 1 Cancer Biology· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:plant (other)· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

H. T. Soh· 2 shared L. Wang· 2 shared L. Zheng· 2 shared M. Eisenstein· 2 shared Q. Ma· 2 shared Y. Mao· 2 shared Y. Wang· 2 shared Y. Xu· 2 shared

Activity by Year

2018-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

H. T. Soh

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Histone marks enable formation of immiscible phase-separated chromatin compartments

W. Sun, J. Wang, W. Liu, B. Tang, H. Qu, J. Wang, H. Li, W. Xie, P. Li

The paper shows that histone marks drive phase-separated chromatin compartments, influencing gene expression and cancer progression through the CBX7-PRC1 complex.

Cell Reports · Jul 1, 2025Peer-reviewedBiochemistry

Trojan horse virus delivering CRISPR-AsCas12f1 controls plant bacterial wilt caused by Ralstonia solanacearum

S. Peng, Y. Xu, H. Qu, F. Nong, F. Shu, G. Yuan, L. Ruan, D. Zheng

This paper develops an engineered filamentous phage that delivers CRISPR-AsCas12f1 to target Ralstonia solanacearum's virulence gene hrpB, effectively controlling bacterial wilt in tobacco.

bioRxiv · Nov 29, 2023 · PreprintMicrobiology

Allosteric Regulation of Aptamer Affinity through Mechano-Chemical Coupling

H. Qu, M. Zheng, Q. Ma, L. Wang, Y. Mao, M. Eisenstein, H. T. Soh, L. Zheng

This paper introduces a method to modulate aptamer affinity using a molecular clamp that destabilizes secondary structure through mechanical tension, demonstrating up to 65-fold affinity changes without prior structural knowledge.

bioRxiv · Jul 28, 2022Biochemistry

VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8+ T cell killing in colorectal cancer

L. Yang, X. Dong, Z. Liu, X. Huang, J. Tan, T. Wen, H. Qu, Z. Wang

This study identifies VPS9D1-AS1 as a lncRNA that enhances TGF-β signaling and immune evasion in colorectal cancer by modulating translation and ISG expression.

bioRxiv · May 12, 2022Cancer Biology

Detection of low numbers of bacterial cells in pharmaceutical drug product using Raman Spectroscopy and PLS-DA multivariate analysis.

R. A. Grosso, A. R. Walther, E. Brunbech, A. Sorensen, B. Schebye, K. E. Olsen, H. Qu, M. A. Hedegaard, E. C. Arnspang

This study detects bacterial contamination in drug products below 10 CFU/ml using Raman spectroscopy and PLS-DA, achieving 99% accuracy.

bioRxiv · Apr 26, 2022Bioengineering

Measuring aptamer folding energy using a molecular clamp

H. Qu, Q. Ma, L. Wang, Y. Mao, M. Eisenstein, H. T. Soh, L. Zheng

This paper introduces a method to measure aptamer folding energy using a molecular clamp and validates it with experimental results for two aptamers.

bioRxiv · Feb 10, 2020Biophysics

Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

J. Jiao, M. He, S. A. Port, R. W. Baker, Y. Xu, H. Qu, Y. Xiong, Y. Wang, H. Jin, T. J. Eisemann, F. M. Hughson, Y. Zhang

This study shows Munc18-1 facilitates SNARE assembly by forming a template complex, and similar mechanisms are used by other SM proteins.

bioRxiv · Sep 10, 2018Biophysics

RNA-Seq analysis of compatible and incompatible styles of Pyrus species at the beginning of pollination

Y. Guan, K. Li, Y. Wang, C. Ma, H. Qu

The paper compares gene expression in compatible and incompatible pollination styles of Pyrus species, identifying pathways and genes involved in self-incompatibility.

bioRxiv · Jun 11, 2018Plant Biology